Reactions are not fun. The rituxin caught up with me and gave me such severe knee and ankle pain that I was unable to walk for a night. The next morning my legs were still weak but it's eased up. I also have sores on my tongue and back of throat. Blah. I'm worried to have it again but they think I need it more than not. Idk. After these treatments I'm just going to see hpw my platelets are for awhile on their own. I think a lot of this treatment is pointless.